Can be the result of drugs (e.g., leflunomide, tumor necrosis factor blockers) Can be a mononeuropathy multiplex pattern or symmetric. Seen in a variety of conditions RA, SLE, MCTD. Length-dependent, pure small fiber and/or ganglionopathy Numerous agents, many of which confer reduced sensory nerve action potentials on NCS Prominent autonomic involvementĬonsider in patients with alcohol abuse, malabsorption, total parenteral nutrition, and bariatric surgeryī 1, B 6, B 12, homocysteine, vitamin E, copper level, methylmalonic acid levels Typically painful dysesthesia of the hands and feet. Monoclonal gammopathy (e.g., Amyloidosis, MM, MGUS, WM, POEMS) Most typically carpal tunnel syndrome, rarely generalized, painful sensory polyneuropathy ![]() ![]() Paraneoplastic panel (i.e., anti-Hu and -CV2 antibodies are relevant to neuropathy)Ĭan present as distal symmetric sensory/sensorimotor polyneuropathy, autonomic neuropathy, mononeuropathy, or multiple mononeuropathies Often associated with encephalitis, cerebellar ataxia, opsoclonus-myoclonus syndrome, and Lambert-Eaton myasthenic syndrome, among others Symmetric distal, demyelinating, polyradiculopathy, or mononeuropathy
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